Amino acid residues Ala283 and His421 in the RNA-dependent RNA polymerase of porcine reproductive and respiratory syndrome virus play important roles in viral ribavirin sensitivity and quasispecies diversity-Reference-Cited by-同舟云学术

Amino acid residues Ala283 and His421 in the RNA-dependent RNA polymerase of porcine reproductive and respiratory syndrome virus play important roles in viral ribavirin sensitivity and quasispecies diversity

Published:2016-01-01 Issue:1 Volume:97 Page:53-59
ISSN:0022-1317
Container-title:Journal of General Virology
language:en
Short-container-title:

Author:

Tian Debin¹,Meng Xiang-Jin¹

Affiliation:

1. Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA, USA

Publisher

Microbiology Society

Subject

Virology

Reference32 articles.

1. A Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-Escape

2. De Novo Initiation of RNA Synthesis by the Arterivirus RNA-Dependent RNA Polymerase

3. Arbovirus high fidelity variant loses fitness in mosquitoes and mice

4. The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen

5. Residues Arg283, Arg285, and Ile287 in the Nucleotide Binding Pocket of Bovine Viral Diarrhea Virus NS5B RNA Polymerase Affect Catalysis and Fidelity

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