Update: proposed reference sequences for subtypes of hepatitis E virus (species Orthohepevirus A)

Author:

Smith Donald B.1ORCID,Izopet Jacques2,Nicot Florence2ORCID,Simmonds Peter1ORCID,Jameel Shahid3ORCID,Meng Xiang-Jin4ORCID,Norder Heléne5ORCID,Okamoto Hiroaki6ORCID,van der Poel Wim H.M.7,Reuter Gábor8,Purdy Michael A.9

Affiliation:

1. Nuffield Department of Medicine, University of Oxford, Oxford, UK

2. INSERM, UMR1043, Toulouse F-31300, France

3. The Wellcome Trust/DBT India Alliance, Hyderabad, India

4. College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA

5. Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, Sweden

6. Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Tochigi-ken, Japan

7. Wageningen Bioveterinary Research, Wageningen University and Research, Lelystad, The Netherlands

8. Department of Medical Microbiology and Immunology, Medical School, University of Pécs, Pécs, Hungary

9. Centers for Disease Control and Prevention, National Center for HIV/Hepatitis/STD/TB Prevention, Division of Viral Hepatitis, Atlanta, Georgia, USA

Abstract

In this recommendation, we update our 2016 table of reference sequences of subtypes of hepatitis E virus (HEV; species Orthohepevirus A, family Hepeviridae) for which complete genome sequences are available (Smith et al., 2016). This takes into account subsequent publications describing novel viruses and additional proposals for subtype names; there are now eight genotypes and 36 subtypes. Although it remains difficult to define strict criteria for distinguishing between virus subtypes, and is not within the remit of the International Committee on Taxonomy of Viruses (ICTV), the use of agreed reference sequences will bring clarity and stability to researchers, epidemiologists and clinicians working with HEV.

Funder

Wellcome Trust

Santé Publique France

Publisher

Microbiology Society

Subject

Virology

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