ICTV Virus Taxonomy Profile: Filoviridae 2024

Author:

Biedenkopf Nadine1,Bukreyev Alexander2,Chandran Kartik3,Di Paola Nicholas4,Formenty Pierre B. H.5,Griffiths Anthony6,Hume Adam J.6,Mühlberger Elke6,Netesov Sergey V.7,Palacios Gustavo8,Pawęska Janusz T.9,Smither Sophie10,Takada Ayato11,Wahl Victoria12,Kuhn Jens H.13

Affiliation:

1. Philipps-University Marburg, Marburg, Germany

2. The University of Texas Medical Branch at Galveston, Galveston, TX, USA

3. Albert Einstein College of Medicine, New York, USA

4. United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA

5. World Health Organization, Geneva, Switzerland

6. Chobanian and Avedisian School of Medicine, Boston University, Boston, MA, USA

7. Novosibirsk State University, Novosibirsk, Russia

8. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

9. National Institute for Communicable Diseases of the National Health Laboratory Service, Sandringham-Johannesburg, Gauteng, South Africa

10. Dstl, Porton Down, Wiltshire, UK

11. International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan

12. National Biodefense Analysis and Countermeasures Center, Fort Detrick, Frederick, MD, USA

13. Integrated Research Facility at Fort Detrick, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA

Abstract

Filoviridae is a family of negative-sense RNA viruses with genomes of about 13.1–20.9 kb that infect fish, mammals and reptiles. The filovirid genome is a linear, non-segmented RNA with five canonical open reading frames (ORFs) that encode a nucleoprotein (NP), a polymerase cofactor (VP35), a glycoprotein (GP1,2), a transcriptional activator (VP30) and a large protein (L) containing an RNA-directed RNA polymerase (RdRP) domain. All filovirid genomes encode additional proteins that vary among genera. Several filovirids (e.g., Ebola virus, Marburg virus) are pathogenic for humans and highly virulent. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the family Filoviridae, which is available at www.ictv.global/report/filoviridae.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

U.S. Department of Homeland Security

Publisher

Microbiology Society

Subject

Virology

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