Evidence of segment reassortment in Crimean-Congo haemorrhagic fever virus

Author:

Hewson Roger1,Gmyl Anatoly2,Gmyl Larissa2,Smirnova Svetlana E.2,Karganova Galina2,Jamil Bushra3,Hasan Rumina3,Chamberlain John1,Clegg Christopher1

Affiliation:

1. Public Health Affairs, Centre for Applied Microbiology and Research, Health Protection Agency, Porton Down, Salisbury SP4 0JG, UK

2. Chumakov Institute of Poliomyelitis and Viral Encephalitides RAMS, Moscow, Russia

3. Departments of Medicine, Microbiology and Pathology, The Aga Khan University Medical Center, Karachi, Pakistan

Abstract

The complete nucleotide sequences of the small (S) and medium (M) segments of three independent strains of Crimean-Congo haemorrhagic fever (CCHF) virus isolated in Uzbekistan, Iraq and Pakistan have been determined. Partial S and M segment sequences from two additional strains and partial large segment sequences from five strains of CCHF virus have also been obtained. These data have been compiled and compared with published full-length and partial sequences of other CCHF virus strains. Analysis of virus strains for which complete and partial S and M segment sequences are available reveals that the phylogenetic grouping of some strains differ between these two segments. Data provided in this report suggest that this discrepancy is not the result of recombination, but rather the consequence of reassortment events that have occurred in some virus lineages. Although described in other genera of the Bunyaviridae family, this is the first report of segment reassortment occurring in the Nairovirus genus.

Publisher

Microbiology Society

Subject

Virology

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