Human papillomavirus type 16 does not require cathepsin L or B for infection-Reference-Cited by-同舟云学术

Human papillomavirus type 16 does not require cathepsin L or B for infection

Published:2013-08-01 Issue:8 Volume:94 Page:1865-1869
ISSN:0022-1317
Container-title:Journal of General Virology
language:en
Short-container-title:

Author:

Calton Christine M.¹²,Schlegel Angela M.³²,Chapman Janice A.¹²,Campos Samuel K.¹²

Affiliation:

1. Department of Immunobiology, University of Arizona, Tucson, AZ 85721, USA

2. BIO5 Institute, University of Arizona, Tucson, AZ 85721, USA

3. Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA

Abstract

Cathepsin L (CatL) and cathepsin B (CatB) are lysosomal proteases that many viruses utilize for capsid disassembly. We tested whether CatL and CatB are required for infection by human papillomavirus type 16 (HPV16). CatL- and CatB-deficient mouse embryonic fibroblasts had higher levels of infection when compared with wild-type cells. Similar results were obtained in HaCaT keratinocytes treated with CatL- or CatB-specific small interfering RNA. Thus, CatL and CatB are not required for HPV16 infection but instead appear to restrict infection.

Publisher

Microbiology Society

Subject

Virology

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