Absence of canine oral papillomavirus DNA following prophylactic L1 particle-mediated immunotherapeutic delivery vaccination-Reference-Cited by-同舟云学术

Absence of canine oral papillomavirus DNA following prophylactic L1 particle-mediated immunotherapeutic delivery vaccination

Published:2002-09-01 Issue:9 Volume:83 Page:2299-2301
ISSN:0022-1317
Container-title:Journal of General Virology
language:en
Short-container-title:

Author:

Moore R. A.¹,Nicholls P. K.¹,Santos E. B.¹,Gough G. W.²,Stanley M. A.¹

Affiliation:

1. Department of Pathology, Cambridge University, Cambridge CB2 1QP, UK1

2. Glaxo Smithkline Research and Development, Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, UK2

Abstract

In the canine oral papillomavirus (COPV) model, following wart regression, COPV DNA was detected by PCR at the challenge site. However, following particle-mediated immunotherapeutic delivery (PMID) of COPV L1 and subsequent challenge, no COPV DNA could be detected. These data support PMID of COPV L1 as a protective vaccine and suggest that PMID of L1 may induce virus clearance.

Publisher

Microbiology Society

Subject

Virology

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