Sustained G→A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome-Reference-Cited by-同舟云学术

Sustained G→A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome

Published:2002-04-01 Issue:4 Volume:83 Page:801-805
ISSN:0022-1317
Container-title:Journal of General Virology
language:en
Short-container-title:

Author:

Vartanian Jean-Pierre¹,Henry Michel¹,Wain-Hobson Simon¹

Affiliation:

1. Unité de Rétrovirologie Moléculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France1

Abstract

Two full-length human immunodeficiency virus type 1 O sequences are described, one of which was hypermutated in all regions of the genome. This indicates that the intracellular [dTTP]/[dCTP] bias conducive to G→A hypermutation may be sustained throughout the synthesis of minus-strand DNA. In turn, this suggests the possibility of mutation of host sequences.

Publisher

Microbiology Society

Subject

Virology

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