Behavioural changes in the rat following infection with varicella-zoster virus

Author:

Fleetwood-Walker S. M.1,Quinn J. P.1,Wallace C.1,Blackburn-Munro G.1,Kelly B. G.1,Fiskerstrand C. E.1,Nash A. A.1,Dalziel R. G.1

Affiliation:

1. Department of Veterinary Pathology1 and Department of Preclinical Veterinary Sciences2, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK

Abstract

Following the establishment of a chronic varicella-zoster virus infection in the rat, behavioural allodynia and hyperalgesia were observed in the injected, but not the contralateral hind limb up to 33 days post-infection. This model may prove useful in investigating mechanisms involved in the establishment of post-herpetic neuralgia.

Publisher

Microbiology Society

Subject

Virology

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