Genomic dissection of the Vibrio cholerae O-serogroup global reference strains: reassessing our view of diversity and plasticity between two chromosomes-Reference-Cited by-同舟云学术

Genomic dissection of the Vibrio cholerae O-serogroup global reference strains: reassessing our view of diversity and plasticity between two chromosomes

Published:2022-08-05 Issue:8 Volume:8 Page:
ISSN:2057-5858
Container-title:Microbial Genomics
language:en
Short-container-title:

Author:

Murase Kazunori¹²,Arakawa Eiji³,Izumiya Hidemasa³,Iguchi Atsushi⁴,Takemura Taichiro⁵,Kikuchi Taisei⁶¹,Nakagawa Ichiro²,Thomson Nicholas R.⁷⁸,Ohnishi Makoto³,Morita Masatomo³^ORCID

Affiliation:

1. Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan

2. Department of Microbiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

3. Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan

4. Department of Animal and Grassland Sciences, Faculty of Agriculture, University of Miyazaki, Japan

5. Vietnam Research Station, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan

6. Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan

7. London School of Hygiene and Tropical Medicine, London, UK

8. Wellcome Trust Sanger Institute, Hinxton, UK

Abstract

Approximately 200 O-serogroups of

Vibrio cholerae

have already been identified; however, only 2 serogroups, O1 and O139, are strongly related to pandemic cholera. The study of non-O1 and non-O139 strains has hitherto been limited. Nevertheless, there are other clinically and epidemiologically important serogroups causing outbreaks with cholera-like disease. Here, we report a comprehensive genome analysis of the whole set of

V. cholerae

O-serogroup reference strains to provide an overview of this important bacterial pathogen. It revealed structural diversity of the O-antigen biosynthesis gene clusters located at specific loci on chromosome 1 and 16 pairs of strains with almost identical O-antigen biosynthetic gene clusters but differing in serological patterns. This might be due to the presence of O-antigen biosynthesis-related genes at secondary loci on chromosome 2.

Publisher

Microbiology Society

Subject

General Medicine

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