Discordant bioinformatic predictions of antimicrobial resistance from whole-genome sequencing data of bacterial isolates: an inter-laboratory study

Author:

Doyle Ronan M.12ORCID,O'Sullivan Denise M.3ORCID,Aller Sean D.4ORCID,Bruchmann Sebastian5ORCID,Clark Taane6ORCID,Coello Pelegrin Andreu78,Cormican Martin9ORCID,Diez Benavente Ernest6ORCID,Ellington Matthew J.10ORCID,McGrath Elaine11,Motro Yair12ORCID,Phuong Thuy Nguyen Thi13,Phelan Jody6ORCID,Shaw Liam P.14ORCID,Stabler Richard A.15ORCID,van Belkum Alex8,van Dorp Lucy16ORCID,Woodford Neil10,Moran-Gilad Jacob12ORCID,Huggett Jim F.173,Harris Kathryn A.2ORCID

Affiliation:

1. Clinical Research Department, London School of Hygiene and Tropical Medicine, London, UK

2. Microbiology Department, Great Ormond Street Hospital NHS Foundation Trust, London, UK

3. Molecular and Cell Biology Team, National Measurement Laboratory, Queens Road, Teddington, Middlesex, UK

4. Institute for Infection and Immunity, St George’s, University of London, Cranmer Terrace, London, UK

5. Pathogen Genomics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK

6. Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK

7. Vaccine and Infectious Disease Institute, Laboratory of Medical Microbiology, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium

8. Clinical Unit, bioMérieux, La Balme Les Grottes, France

9. National University of Ireland Galway, Galway, Ireland

10. NIS Laboratories, National Infection Service, Public Health England, London, UK

11. Carbapenemase-Producing Enterobacterales Reference Laboratory, Department of Medical Microbiology, University Hospital Galway, Galway, Ireland

12. School of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel

13. Department of BiNano Technology, College of BiNano Technology, Gachon University, Seoul, Republic of Korea

14. Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK

15. AMR Centre, London School of Hygiene and Tropical Medicine, London, UK

16. UCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, Gower Street, London, UK

17. School of Biosciences and Medicine, Faculty of Health and Medical Science, University of Surrey, Guildford, UK

Funder

European Metrology Programme for Innovation and Research

EU Horizon 2020

Publisher

Microbiology Society

Subject

General Medicine

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