Genomic epidemiology of nontoxigenic Corynebacterium diphtheriae from King County, Washington State, USA between July 2018 and May 2019

Author:

Xiaoli Lingzi1,Benoliel Eileen2,Peng Yanhui3,Aneke Janessa1ORCID,Cassiday Pamela K.3ORCID,Kay Meagan2,McKeirnan Shelly2,Duchin Jeffery S.2,Kawakami Vance2ORCID,Lindquist Scott4,Acosta Anna M.3ORCID,DeBolt Chas4ORCID,Tondella Maria Lucia3,Weigand Michael R.3ORCID

Affiliation:

1. IHRC, Inc., Atlanta, Georgia, USA

2. Public Health Seattle and King County, Seattle, WA, USA

3. Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA

4. Washington State Department of Health, Shoreline, WA, USA

Abstract

Between July 2018 and May 2019, Corynebacterium diphtheriae was isolated from eight patients with non-respiratory infections, seven of whom experienced homelessness and had stayed at shelters in King County, WA, USA. All isolates were microbiologically identified as nontoxigenic C. diphtheriae biovar mitis. Whole-genome sequencing confirmed that all case isolates were genetically related, associated with sequence type 445 and differing by fewer than 24 single-nucleotide polymorphisms (SNPs). Compared to publicly available C. diphtheriae genomic data, these WA isolates formed a discrete cluster with SNP variation consistent with previously reported outbreaks. Virulence-related gene content variation within the highly related WA cluster isolates was also observed. These results indicated that genome characterization can readily support epidemiology of nontoxigenic C. diphtheriae .

Funder

Centers for Disease Control and Prevention

Publisher

Microbiology Society

Subject

General Medicine

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