Interpretive criteria to differentiate low- and high-level mupirocin resistance in Staphylococcus aureus

Author:

Moreira de Oliveira Naira Elane1,Cardozo Ana Paula Couto Marques1,Marques Elizabeth de Andrade2,Netto dos Santos Kátia Regina1,deMarval Marcia Giambiagi1

Affiliation:

1. Instituto de Microbiologia Prof. Paulo de Góes, Universidade Federal do Rio de Janeiro, RJ, Brazil

2. Faculdade de Ciências Medicas, Universidade do Estado do Rio de Janeiro, RJ, Brazil

Abstract

Meticillin-resistant Staphylococcus aureus isolates were classified into three mupirocin susceptibility groups by the disc diffusion method using 5 and 200 μg mupirocin discs. The zone diameter observed for a 5 μg disc distinguished MupS from the resistant strains (either MupRL or MupRH). On the other hand, a 200 μg disc distinguished the high-resistance MupRH strains from the other two (MupS or MupRL). Thus, the concomitant use of 5 and 200 μg mupirocin discs allowed the clear distinction among the three mupirocin susceptibility groups, MupS, MupRL or MupRH.

Publisher

Microbiology Society

Subject

Microbiology (medical),General Medicine,Microbiology

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