1. Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 2Beijing BGI-GBI Biotech Co. Ltd, Beijing 101300, China 3Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China 4Beijing 302 Hospital, Beijing 100039, China 5Beijing 301 Hospital, Beijing 100853, China 6Beijing Union Hospital, Beijing 100730, China 7Beijing Red Cross Blood Center, Beijing 100088, China