Epidemiology of Enterobacter cloacae strains producing a carbapenemase or metallo-beta-lactamase in Vietnamese clinical settings in 2014

Epidemiology of Enterobacter cloacae strains producing a carbapenemase or metallo-beta-lactamase in Vietnamese clinical settings in 2014–2017

Published:2020-04-01 Issue:4 Volume:69 Page:530-536
ISSN:0022-2615
Container-title:Journal of Medical Microbiology
language:en
Short-container-title:

Author:

Miyoshi-Akiyama Tohru¹,Ohmagari Norio²,Phuong Truong Thai³,Huy Nguyen Quang³,Anh Nguyen Quoc³,Van Thanh Do³^ORCID,Thuy Pham Thi Phuong⁴,Kirikae Teruo⁵⁶,Nhung Pham Hong³,Takemoto Norihiko¹

Affiliation:

1. Pathogenic Microbe Laboratory, Research Institute, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan

2. Disease Control and Prevention Center, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku-ku, Tokyo 162-8655, Japan

3. Bach Mai Hospital. 78 Gia Phong Road, Phuong Mai, Dong Da district, Hanoi, Vietnam

4. NCGM-Bach Mai Hospital Medical Collaboration Center, 78 Gia Phong Road, Phuong Mai, Dong Da district, Hanoi, Vietnam

5. Present address: Department of Microbiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

6. Department of Infectious Diseases, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku-ku, Tokyo 162-8655, Japan

Abstract

Introduction. Little is known about the epidemiology of

Enterobacter cloacae

strains producing a carbapenemase or metallo-beta-lactamase in Vietnamese hospitals. Aim. This study analysed

E. cloacae

strains resistant to imipenem or meropenem that had been isolated from patients admitted to one of the largest hospitals in Vietnam in 2014–2017. Methodology. Eighteen Vietnamese (VN) strains were subjected to whole-genome sequencing and their sequences compared with those of 17

E. cloacae

strains carrying a carbapenemase or metallo-beta-lactamase in the database (db strains). Results. Although the distribution of virulence factors did not differ significantly between VN and db strains, all 18 VN isolates harboured blaNDM-1, phylogenetic analysis revealed a high clonality of the VN strains. Bayesian phylogenetic analysis suggested that the VN strains speciated relatively recently. Conclusions. Several prevalent clones of carbapenem-resistant

E. cloacae

have circulated within Vietnamese hospitals. Adequate measures are needed to prevent their further spread.

Funder

Japan Agency for Medical Research and Development

Publisher

Microbiology Society

Subject

Microbiology (medical),General Medicine,Microbiology

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