Two cases of failed ceftriaxone treatment in pharyngeal gonorrhoea verified by molecular microbiological methods-Reference-Cited by-同舟云学术

Two cases of failed ceftriaxone treatment in pharyngeal gonorrhoea verified by molecular microbiological methods

Published:2009-05-01 Issue:5 Volume:58 Page:683-687
ISSN:0022-2615
Container-title:Journal of Medical Microbiology
language:en
Short-container-title:

Author:

Tapsall John¹,Read Phillip²,Carmody Christopher³,Bourne Christopher²,Ray Sanghamitra¹,Limnios Athena¹,Sloots Theo⁴,Whiley David⁴

Affiliation:

1. World Health Organization Collaborating Centre for STD, Prince of Wales Hospital, Sydney, Australia

2. Sydney Sexual Health Centre, Sydney Hospital, Sydney, Australia

3. Short Street Sexual Health Clinic, St George Hospital, Sydney, Australia

4. Queensland Paediatric Infectious Diseases Laboratory, Sir Albert Sakzewski Virus Research Centre, Royal Children's Hospital and Health Service District, Queensland, Australia

Abstract

Diagnostic, genotypic and antibiotic-resistance determinants of Neisseria gonorrhoeae were analysed by molecular methods to verify the failure of ceftriaxone treatment in two cases of pharyngeal gonorrhoea. Monoplex assays were needed to define competitive inhibition of a positive Chlamydia PCR in a duplex assay. Different penA changes were detected in the N. gonorrhoeae isolated from the two cases. These were associated with raised ceftriaxone MICs of 0.03 and 0.016 mg l−1, which may have contributed to the treatment failures in these cases.

Publisher

Microbiology Society

Subject

Microbiology (medical),General Medicine,Microbiology

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