Breast cancer-associated protein – a novel binding partner of Mason-Pfizer monkey virus protease-Reference-Cited by-同舟云学术

Breast cancer-associated protein – a novel binding partner of Mason-Pfizer monkey virus protease

Published:2014-06-01 Issue:6 Volume:95 Page:1383-1389
ISSN:0022-1317
Container-title:Journal of General Virology
language:en
Short-container-title:

Author:

Rumlová Michaela¹²,Křížová Ivana²,Hadravová Romana²,Doležal Michal³²,Strohalmová Karolína³²,Keprová Alena³²,Pichová Iva²,Ruml Tomáš³

Affiliation:

1. Department of Biotechnology, Institute of Chemical Technology, Technická 5, 166 28 Prague, Czech Republic

2. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., IOCB & Gilead Research Center, Flemingovo nám. 2, 166 10 Prague, Czech Republic

3. Department of Biochemistry and Microbiology, Institute of Chemical Technology, Technická 5, 166 28 Prague, Czech Republic

Abstract

We identified breast cancer-associated protein (BCA3) as a novel binding partner of Mason-Pfizer monkey virus (MPMV) protease (PR). The interaction was confirmed by co-immunoprecipitation and immunocolocalization of MPMV PR and BCA3. Full-length but not C-terminally truncated BCA3 was incorporated into MPMV virions. We ruled out the potential role of the G-patch domain, a glycine-rich domain located at the C terminus of MPMV PR, in BCA3 interaction and virion incorporation. Expression of BCA3 did not affect MPMV particle release and proteolytic processing; however, it slightly increased MPMV infectivity.

Publisher

Microbiology Society

Subject

Virology

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