The PI3K pathway acting on alternative HIV-1 pre-mRNA splicing-Reference-Cited by-同舟云学术

The PI3K pathway acting on alternative HIV-1 pre-mRNA splicing

Published:2014-08-01 Issue:8 Volume:95 Page:1809-1815
ISSN:0022-1317
Container-title:Journal of General Virology
language:en
Short-container-title:

Author:

Hillebrand Frank¹²,Erkelenz Steffen¹,Diehl Nora¹,Widera Marek¹,Noffke Juliane³,Avota Elita⁴,Schneider-Schaulies Sibylle⁴,Dabauvalle Marie-Christine²,Schaal Heiner¹

Affiliation:

1. Institute for Virology, Universitaetsklinikum Duesseldorf, Universitaetsstr. 1, D-40225 Duesseldorf, Germany

2. Central Division for Electron Microscopy, University of Wuerzburg, Am Hubland, D-97074 Wuerzburg, Germany

3. Department of Dermatology, Universitaetsklinikum Duesseldorf, Moorenstrasse 5, D-40225 Duesseldorf, Germany

4. Institute for Virology and Immunobiology, University of Wuerzburg, Versbacher Str. 7, D-97078 Wuerzburg, Germany

Abstract

HIV-1 mediates pro-survival signals and prevents apoptosis via the phosphatidylinositol-3-kinase (PI3K) pathway. This pathway, however, also affects phosphorylation of serine-arginine (SR) proteins, a family of splicing regulatory factors balancing splice site selection. We now show that pharmacologic inhibition of PI3K signalling alters the HIV-1 splicing pattern of both minigene- and provirus-derived mRNAs. This indicates that HIV-1 might also promote PI3K signalling to balance processing of its transcripts by regulating phosphorylation of splicing regulatory proteins.

Publisher

Microbiology Society

Subject

Virology

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