A novel, divergent simian T-cell lymphotropic virus type 3 in a wild-caught red-capped mangabey (Cercocebus torquatus torquatus) from Nigeria-Reference-Cited by-同舟云学术

A novel, divergent simian T-cell lymphotropic virus type 3 in a wild-caught red-capped mangabey (Cercocebus torquatus torquatus) from Nigeria

Published:2003-10-01 Issue:10 Volume:84 Page:2723-2727
ISSN:0022-1317
Container-title:Journal of General Virology
language:en
Short-container-title:

Author:

Meertens L.¹,Shanmugam V.²,Gessain A.¹,Beer B. E.³,Tooze Z.⁴,Heneine W.²,Switzer W. M.²

Affiliation:

1. Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Département d'Ecosystème et Epidémiologie des Maladies Infectieuses, Batiment Lwoff, Institut Pasteur, 25–28 rue du Dr Roux, 75724 Paris Cedex 15, France

2. HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS G-19, Atlanta, GA 30333, USA

3. Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, MD 20852, USA

4. Cercopan, Calabar, CRS, Nigeria

Abstract

We present here a novel, distinct simian T-cell lymphotropic virus (STLV) found in a red-capped mangabey (Cercocebus torquatus) (CTO-NG409), wild-caught in Nigeria, that showed an HTLV-2-like Western blot (WB) seroreactivity. The complete genome (8920 bp) of CTO-NG409 STLV was related to but different from STLV-3/PHA-PH969 (13·5 %) and STLV-3/PPA-F3 (7·6 %), and STLV-3/CTO604 (11·3 %), found in Eritrean and Senegalese baboons, and red-capped mangabeys from Cameroon, respectively. Phylogenetic analysis of a conserved tax (180 bp) sequence and the env gene (1482 bp) confirmed the relatedness of STLV-3/CTO-NG409 to the STLV-3 subgroup. Molecular clock analysis of env estimated that STLV-3/CTO-NG409 diverged from East and West/Central African STLV-3s about 140 900±12 400 years ago, suggesting an ancient African origin of STLV-3. Since phylogenetic evidence suggests multiple interspecies transmissions of STLV-1 to humans, and given the antiquity and wide distribution of STLV-3 in Africa, a search for STLV-3 in human African populations with HTLV-2-like WB patterns is warranted.

Publisher

Microbiology Society

Subject

Virology

Reference19 articles.

1. Characterization of novel simian immunodeficiency viruses from red-capped mangabeys from Nigeria (SIVrcmNG409 and -NG411);Beer;J Virol,2001

2. Absence of evidence of infection with divergent primate T-lymphotropic viruses in United States blood donors who have seroindeterminate HTLV test results;Busch;Transfusion,2000

3. Molecular epidemiology of human T cell leukemia/lymphoma viruses type1 and type 2 (HTLV-1/2) and related simian retroviruses (STLV-1, STLV-2 and STLV-L/3);Gessain,2002

4. Isolation of a novel simian T-cell lymphotropic virus from Pan paniscus that is distantly related to the human T-cell leukemia/lymphotropic virus types I and II;Giri;J Virol,1994

5. A primate T-lymphotropic virus, PTLV-L, different from human T-lymphotropic viruses types I and II, in a wild-caught baboon ( Papio hamadryas );Goubau;Proc Natl Acad Sci U S A,1994

Cited by 23 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Human T-cell lymphotropic virus type 1 transmission dynamics in rural villages in the Democratic Republic of the Congo with high nonhuman primate exposure;PLOS Neglected Tropical Diseases;2021-01-28

2. Discovery and Characterization of Auxiliary Proteins Encoded by Type 3 Simian T-Cell Lymphotropic Viruses;Journal of Virology;2015-01-15

3. Emergence of Novel Retroviruses;Emerging Infections 7;2014-04-30

4. HTLV-3/4 and simian foamy retroviruses in humans: Discovery, epidemiology, cross-species transmission and molecular virology;Virology;2013-01

5. Animal models on HTLV-1 and related viruses: what did we learn?;Frontiers in Microbiology;2012