Vaccinia virus: shedding and horizontal transmission in a murine model-Reference-Cited by-同舟云学术

Vaccinia virus: shedding and horizontal transmission in a murine model

Published:2008-12-01 Issue:12 Volume:89 Page:2986-2991
ISSN:0022-1317
Container-title:Journal of General Virology
language:en
Short-container-title:

Author:

Ferreira Jaqueline Maria Siqueira¹,Abrahão Jônatas Santos¹,Drumond Betânia Paiva¹,Oliveira Fernando Meireles¹,Alves Pedro Augusto¹,Pascoal-Xavier Marcelo Antônio¹,Lobato Zélia Inês Portela²,Bonjardim Cláudio Antônio¹,Ferreira Paulo César Peregrino¹,Kroon Erna Geessien¹

Affiliation:

1. Laboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, CEP 31270-901, Belo Horizonte, MG, Brazil

2. Laboratório de Vírus, Departamento de Medicina Veterinária Preventiva, Escola de Veterinária, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, CEP 31270-901, Belo Horizonte, MG, Brazil

Abstract

Vaccinia virus (VACV) has been associated with several bovine vaccinia outbreaks in Brazil, affecting cattle and humans. There are no available data about VACV environmental circulation or the role of wildlife in the emergence of an outbreak. Since VACV was isolated from rodents in Brazil, we investigated shedding and transmission of VACV strains in mice. The VACV excretion profile was assessed by PCR and chicken chorioallantoic membrane infection, revealing viral DNA and infectious virus in the faeces and urine of intranasally infected mice. Horizontal transmission was assessed by exposure of sentinel mice to wood shavings contaminated with excrement, to mimic a natural infection. Sentinel mice showed orthopoxvirus antibodies, and VACV DNA and infectious virus were detected in their faeces and intestines, even after six rounds of natural transmission. Together, these data suggest that murine excrement could play a relevant role in VACV spread and transmission, perhaps helping to explain how these viruses circulate between their natural hosts.

Publisher

Microbiology Society

Subject

Virology

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