Genomic and antigenic characterization of Jos virus

Author:

Bussetti Ana Valeria1,Palacios Gustavo1,Travassos da Rosa Amelia2,Savji Nazir1,Jain Komal1,Guzman Hilda2,Hutchison Stephen3,Popov Vsevolod L.2,Tesh Robert B.2,Lipkin W. Ian1

Affiliation:

1. Center for Infection and Immunity and WHO Collaborating Centre for Diagnostics, Surveillance and Immunotherapeutics for Emerging Infectious and Zoonotic Diseases, Mailman School of Public Health, Columbia University, New York, NY, USA

2. Center for Biodefense and Emerging Infectious Diseases, Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA

3. 454 Life Sciences, A Roche Company, Branford, CT, USA

Abstract

Jos virus (JOSV), originally isolated in Jos, Nigeria in 1967, has remained unclassified despite cultivation in tissue culture, development of animal models of infection and implementation of seroprevalence surveys for infection. Here, we report genetic, ultrastructural and serological evidence that JOSV is an orthomyxovirus distinct from but phylogenetically related to viruses of the genus Thogotovirus.

Publisher

Microbiology Society

Subject

Virology

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