Genomic characterization of a novel human adenovirus type 31 recombinant in the hexon gene-Reference-Cited by-同舟云学术

Genomic characterization of a novel human adenovirus type 31 recombinant in the hexon gene

Published:2011-12-01 Issue:12 Volume:92 Page:2770-2775
ISSN:0022-1317
Container-title:Journal of General Virology
language:en
Short-container-title:

Author:

Matsushima Yuki¹,Shimizu Hideaki¹,Phan Tung Gia²,Ushijima Hiroshi³

Affiliation:

1. Division of Virology, Kawasaki City Institute of Public Health, 5-13-10 Oshima, Kawasaki-ku, Kawasaki 210-0834, Japan

2. Blood Systems Research Institute, 270 Masonic Avenue, San Francisco, CA 94118, USA

3. Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, 30-1 Oyaguchi Kamicho, Itabashi-ku, Tokyo 173-8610, Japan

Abstract

A novel human recombinant adenovirus of species A (HAdV-A31 MZ) was isolated from a patient with acute gastroenteritis in Japan. The complete genome of HAdV-A31 strain MZ contains 33 776 bp. Analysis of the hexon gene of HAdV-A31 MZ indicated that its hexon sequence is the result of a genetic recombination between those of HAdV-A31 and a close relative to HAdV-A12. The recombination sites were found around the border of hypervariable loops 1 and 2 in the hexon gene, which are the most important determinants for virus neutralization. Loops 1 and 2 of this virus were genetically related to HAdV-A12, whereas all other parts of the genome were highly similar to HAdV-A31. In order to understand the evolution of adenoviruses correctly and to avoid misidentification of HAdV types, we recommend characterizing not only the hexon gene, but also the penton base and fiber genes.

Publisher

Microbiology Society

Subject

Virology

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