1. School of Life Science, Liaoning University, Shenyang 110036, PR China
2. Liaoning Engineering Laboratory for Molecular Simulation and Designing of Drug Molecules, Shenyang 110036, PR China
3. Research Center for Computer Simulating and Information Processing of Bio-macromolecules of Liaoning, Shenyang 110036, PR China
4. School of Basic Medical Science, Shenyang Medical College, Shenyang 110034, PR China
5. School of Pharmacy, Liaoning University, Shenyang 110036, PR China