Author:
Nandurkar Deweshri,Danao Kishor,Rokde Vijayshri,Shivhare Ruchi,Mahajan Ujwala
Abstract
Pyrazoles have a wide range of applications in medicinal chemistry, drug discovery, agrochemistry, coordination chemistry, and organometallic chemistry. Their popularity has skyrocketed since the early 1990s. Basically, Pyrazole (C3H3N2H) is a simple doubly unsaturated five membered heterocyclic aromatic ring molecule comprising two nitrogen (N) atoms at positions 1- and 2- and three carbon (C) atoms. Pyrazole nucleus is synthesized with various strategies such as multicomponent approach, dipolar cycloadditions, cyclocondensation of hydrazine with carbonyl system, using heterocyclic system and multicomponent approach. A special emphasis is placed on a thorough examination of response processes. Furthermore, the reasons for the increasing popularity of pyrazoles in several fields of science are examined. Pyrazoles have recently been the focus of many techniques, mostly because of how frequently they are used as scaffolds in the synthesis of bioactive chemicals and reactions in various media. The goal of this chapter is to discuss the current developments in synthetic techniques and biological activity related to pyrazole derivatives. The many pharmacological functions of the pyrazole moiety and different synthesis techniques were discussed. This chapter has summarized novel strategies and wide applications of pyrazole scaffold.
Reference64 articles.
1. Eicher T, Hauptmann S, Speicher A. The Chemistry of Heterocycles: Structure, Reactions Synthesis and Applications. 2nd ed. Weinheim: Wiley-VCH; 2003
2. Alam MJ, Alam O, Alam P, Naim MJ. A review on pyrazole chemical entity and biological activity. International Journal of Pharmaceutical Sciences and Research. 2015;6:1433-1442
3. Dash B, Karim S. Pyrazoline heterocyclic: A review. International Journal of Pharmaceutical Sciences and Research. 2021;12:2570-2588
4. Jamwal A, Javed A, Bhardwaj V. A review on Pyrazole derivatives of pharmacological potential. Journal of Pharmaceutical and Biological Sciences. 2013;3:114-123
5. Dewangan D, Kumar T, Alexander A, Nagori K, Tripathi DK. Pyrazole: Their chemistry and pharmacological potentials: A review. Journal of Current Pharma Research. 2011;1(4):369-374