Changes in Vitamin B12, Iron, Thyroid Hormones, Thyroid Autoantibodies and Hematological Indices Levels in Patients Suffering from Helicobacter pylori Infection

Abstract

Helicobacter pylori infection has been recognized as a public health problem worldwide with raising prevalence in developing than the developed countries. More than 50% of the world’s population infected, and 80% of infected have no symptoms. Megaloblastic anemia can occur due to impaired DNA synthesis resulting from deficiencies of vitamin B12 and folate. The development of autoantibodies to thyroid peroxidase (anti-TPO), thyroglobulin (anti-Tg), and thyroid-stimulating hormone receptor (TSH-R) is the main characteristic of autoimmune thyroid disease. H. pylori may decrease absorption of oral thyroxine by decreasing gastric acid secretion in the stomach. H. pylori has important role of in the development of autoimmune thyroid diseases, vitamin B12 deficiency and malfunctions of human. The primary goal of this chapter is to observe association between H. pylori infection in the gastric mucosa and of autoimmune thyroid diseases vitamin B12 deficiency because eradication of H. pylori can prevent the development of complications.