A Patient-Centered Management of Patients with Diabetes Type 2: Are All Diabetic Patients the Same?

Abstract

Type 2 diabetes is a complicated condition that develops as a result of the interplay of several genetic variations with a person’s lifestyle and environmental circumstances. Due to its strong ties to aging, it adds to the complexity of these patients and raises the risk that geriatric diseases like sarcopenia, malnutrition, and frailty might appear in them. In fact, chronic inflammation is thought to be the primary mechanism causing metabolic and vascular alterations as people age. There is still little knowledge about the phases of chronic inflammation that influence the development of damage to target organs, and there is also limited knowledge about the relationship between chronic inflammation and metabolic diseases. The interindividual variability in type 2 diabetes patients is further exacerbated by aging-related alterations in inflammatory and metabolic markers. Clustering, or the grouping of individuals, can help identify novel type 2 diabetes phenotypes and further clarify the pathophysiological causes of the condition. The aim of this work is to identify a potential model of treatment personalization that could be especially helpful for family medicine physicians who regularly treat complex heterogeneous patients in light of the rising demand for personalized care for patients with type 2 diabetes.