Bacterial Biofilm: Contribution to AMR and Approaches to Tackle

Abstract

The brisk emergence of resistant microbes is occurring worldwide, endangering the efficacy of various antimicrobial agents. The overprescription of antimicrobial drugs results in the emergence of mutant strains of drug-resistant pathogens challenging the existing antimicrobial regime. Moreover, the outbreak of the pandemic has emphasized the necessity to consider the coinfections and antimicrobial resistance crisis as a vital motive of morbidity and mortality. Therefore, the prevention of such infections is much better than the eradication of the same. Thus, herein, we aim at providing a comprehensive list that can be used as an alternative class of antibacterial agents by exploiting the activity of various phytochemicals. The antibiofilm activity of various classes of phytochemicals would be projected for both the eradication and the prevention of biofilm formation in the presence of selected compounds. This chapter visualizes antimicrobial resistance as a matter of grave concern and one of the greatest threats to global health, food security, and development today.