Classification and Clinical Features of Pulmonary Hypertension in Adults

Abstract

This chapter explores the clinical manifestations and initial diagnostic findings associated with pulmonary hypertension (PHTN) at different stages. The definition of PHTN, as proposed in the 6th World Symposium, considers a mean pulmonary arterial pressure at rest (mPAP) of greater than 20 mmHg (previously 25 mmHg) and a pulmonary vascular resistance equal to or exceeding 3 WU. PHTN is clinically classified into five groups: Group 1 includes idiopathic, hereditary, and other forms; Group 2 comprises PHTN due to left heart disease; Group 3 consists of PHTN associated with pulmonary diseases or hypoxia; Group 4 pertains to PHTN caused by pulmonary artery obstruction; and Group 5 encompasses cases with unclear or multifactorial etiologies. The classification of PHTN into these groups holds significant clinical value as it contributes to determining survival rates and treatment responses. The chapter elaborates on the clinical features observed throughout various stages of PHTN and highlights the abnormalities detected during initial diagnostic assessments. The in-depth details will also be outlined in subsequent chapters of the book.