Combining PDO Threads with Exosomes for Microlifting

Abstract

A recent survey of practicing plastic surgeons showed that regenerative medicine is the current top interest of esthetic consumers worldwide. Patients are frequently requesting correction of small regions, instead of opting for an all-encompassing procedure associated with prolonged recovery time. Thus, the field of “microlifting” has emerged. This is a new approach in which minimally invasive procedures can be utilized to accomplish outcomes formerly reserved for traditional surgery. The combination of polydioxanone (PDO) threads and topical exosomes is a method of treating both underlying soft tissue laxity and the surface of aging skin. The application of exosomes can deliver topical growth factors and targeted peptides to assist in rapid skin surface healing. More than a simple delivery vesicle, exosomes communicate with cells at the recipient site and can induce cellular change. PDO threads can be used subcutaneously as both a suspension device and regenerative biostimulatory device. Usually resorbed at 6 months post-insertion, these threads leave behind a linear network of collagen and elastin fibers that remains long after the polydioxanone is gone. Combination therapies can target several concerns when performed simultaneously. This regenerative method is well accepted by patients due to minimal cost and recovery time.