Effective techniques in improving stem cell function and success in stem cell transplantation

Abstract

Stem cell-based therapies have been considered as an effective treatment approach during the last few decades. Stem cells are used as a promising tool in the treatment of various diseases due to their unique properties. However, despite the advantages and benefits of stem cells, there are a number of obstacles that lead to poor performance and even death of transplanted stem cells in the host tissue. Therefore, by considering the effective factors in stem cell transplantation, including the system of transferring stem cells and the desired conditions and environment in the host tissue, which are effective in increasing the survival and function of these cells, we can lead to success in stem cell transplantation. Therefore, the design and engineering of scaffolds as a new technology leads to an increase in the efficiency of stem cells. Autologous serum condition (ASC) and human platelet lysate (HPL) provide the necessary requirements for the success of stem cell transplantation. They have been noticed because of their many advantages. Current research is focusing on developing biomaterials and blood product injections to protect cells during delivery and to stimulate endogenous regeneration through interactions of transplantation cells and the host tissue.