Abstract
Short-term biological indicator of urinary Na and K excretion is generally used to assess Na and K dietary exposure. In this study, we used the long-term biological indicator of hair to assess Na and K nutritional status. Hair Na and K were analyzed in 1073 healthy adult white Caucasians [734 women (♀) and 339 men (♂)] with the ICP MS. The log-transformed data were analyzed with median derivatives bioassay. The median values (μg∙g−1) were ♀Na 254 and ♂Na 371, and ♀K 74.3 and ♂K 143, respectively. The linear (adequate) ranges of the sigmoid saturation curve ranges for sodium were ♀Na 55.6–1307 and ♂Na 84.0–1450, whereas these ranges for potassium were ♀K 18.9–467 and ♂K 25.8–1079. The strict homeostatic control of whole blood K and Na renders them unsuitable for assessing the nutritional status. The potassium to sodium ratio (K/Na) in women appears stable across the sigmoid linear segment range, contrary to the constantly increasing K/Na ratio in Men. The results suggest that hair Na concentration should not be below 55.6 and 84.0 or above 1307 and 1450 μg∙g-1 in women and men, respectively. Similarly, K hair concentrations should not be below 18.0 and 25.8 and higher than 46.7 and 107.9 in women and men, respectively. Hair K/Na ratio should stay about 0.600 in M and 0.400 in W. Current dietary salt exposure of the general US population does not require preventive across the board salt restriction.
Reference40 articles.
1. Gaw A, Murphy MJ, Cowan RA, O’Reilly DSJ, Stewart MJ, Shepherd J. Clinical Biochemistry. Edinburgh: Churchill and Livingstone; 2004
2. Emsley J. Nature Building Blocks. Oxford: Oxford University Press; 2003
3. Mente A, O’Donnel MJ, Rangarajan S, McQueen MJ, Poirier P, Wiegelosz A, et al. Association of urinary sodium and potassium excretion with blood pressure. New England Journal of Medicine. 2014;371:601-611
4. O’Donnel MJ, Yusuf S, Mente A, Gao P, Mann JF, Teo K, et al. Urinary sodium and potassium excretion, mortality and cardiovascular events. New England Journal of Medicine. 2014;371:612-623
5. Fillipiou CD, Tsiouif CT, Thomopoluous CG, Mihas CC, Dimitriadis KS, Sotiripoulou L, et al. Dietary approaches to stop hypertension (DASH) diet and blood pressure reduction in adults with and without hypertension: A systemic review and meta analysis of randomized controlled trials. Advances in Nutrition. 2020;11:1-11