Nanostructured Metal Polyacrylates as Both Local Hemostatics and Antimicrobials

Abstract

A methodological approach to directed synthesis of biopharmaceutical composites allows solving an urgent problem: the development of fundamentally new high-molecular materials intended for the interaction of synthetic substances with the biological environment, e.g., with blood. Polymer composites containing ionogenic groups and nanoparticles are capable of complementary conformational transformations and cooperative binding. Functional polymer materials with a wide range of biological activity have been designed on the basis of essential elements and nanoparticles of noble metals. Potential hemostatics with unique properties are proposed. They can be employed as universal agents in a wide variety of surgical operations, as well as for healing the wounds and injuries in case of emergency. At the same time, they stop bleeding even in patients with disorders of the blood coagulation system. The polymer composites can find application as unprecedented, highly effective drugs with a wide range of pharmacological activity. Innovative potential drugs based on polymer composites acting as hemostatics, asepsis, antiseptics without antibiotics, reparants, analgesics, and cytostatics can effectively solve the problems of modern medicine including disaster medicine.