Author:
Bakari Daoudou,Mbala Ekamba Jojo,Hamadou Mamoudou,Garga Yaya,Baane Martin-Paul,Obono Félicité
Abstract
The aim of this study is to determine the types of carbapenemases moving around the city of Maroua with a view to contribute to the development of a control strategy against the enterobacteria that produce them. The investigation carried out on the biological samples showed that 5.97% of the sample contained carbapenem-resistant microorganisms. This includes 2.20% of urine samples, 0.94% of osteitis samples, 0.63% of wound pus samples, 1.26% of stool samples and 0.94% of blood samples. The microorganisms responsible for this resistance to carbapenems are 5.26% for each of species Arizona, Citrobacter braakii, Enterobacter gergoviae, P. vulgaris, and Serratia ficaria, 26.32% for the species E. gergoviae and P. mirabilis and 21.05% for the species S. odorifera 1. All these enterobacteria produce at least one carbapenemase, which 36.84% are of the KPC type, 10.53% of the OXA-48 or OXA-181 type and 52.63% of types that could not be determined by the algorithm proposed by Nordmann et al. used for this purpose. The types of carbapenemases determined in this revealed 11 substrates and inhibition profiles associated with their production. This highlighted the difficulty of applying an inhibition law in situ in the context of probabilistic antibiotic therapy.
Reference44 articles.
1. Ebongue CO, Tsiazok DM, Mefo’o NPJ, Beyiha G, Adiogo D. Evolution de la résistance aux antibiotiques des entérobactéries isolées à l’Hôpital Général de Douala de 2005 à 2012. The Pan African Medical Journal. 2015;20:227. DOI: 10.11604/pamj.2015.20.227.4770
2. Gangoué-Pieboji J, Bedenic B, Koulla-Shiro S, Randegger C, Adiogo D, Ngassam P, et al. Extended spectrum beta lactamase producing enterobacteriaceae in Yaounde, Cameroon. Journal of Clinical Microbiology. 2005;43(7):3273-3277
3. Lonchel CM, Meex C, Gangoué-Piéboji J, Boreux R, Assoumou MC, Melin P, et al. Proportion of extended-spectrum ß-lactamase producing enterobacteriaceae in community setting in Ngaoundere, Cameroon. BMC Infectious Diseases. 2012;12:53. DOI: 10.1186/1471-2334-12-53
4. Fedama WM, Kingserbe L. Mécanismes de résistance aux antibiotiques des bactéries isolées des viandes de bœuf vendues dans les abattoirs et quelques points de ventes de la ville de Maroua (Mémoire DIPES II). Maroua, Cameroun: Université de Maroua; 2017. p. 48
5. Naoupoul A. Mécanismes de résistance des bactéries isolées des yaourts vendus dans quelques sites de la ville de Maroua-Cameroun (Mémoire de Master). Ngaoundéré, Cameroun: Université de Ngaoundéré; 2017. p. 72