Author:
Goyal Vinod,Bandari Mahalakshmi
Abstract
Animals, especially rodents, are an integral part of any drug discovery and development program. Once initial in silico and in vitro experiments are completed, a new chemical is tested for its pharmacokinetic profile, efficacy, and safety in animals, rodents being the most commonly used animals. Millions of rodents (rats and mice) are being used annually to understand the properties of new chemicals. Apart from wild types, genetically modified rats and mice such as knock-out or knock-in animals are very popular nowadays in understanding the biology behind diseases. Though the emergence of advanced technologies undermines the use of rodents in research, replacing animal use in research now seems to be a dream.
Reference37 articles.
1. Smith JR, Bolton ER, Dwinell MR. The Rat: A Model Used in Biomedical Research. Methods in Molecular Biology. 2019;:1-41. DOI: 10.1007/978-1-4939-9581-3_1
2. National Academies of Sciences, Engineering, and Medicine. 1991. Available from:
3. Position statement on the use of animals in research. NIH Guide. 26 Feb 1993;(8)
4. Bryda EC. The mighty mouse: The impact of rodents on advances of biomedical research. Missouri Medicine. 2013;:3
5. How genetically similar are we to other life forms. 2021. Available from: