Abstract
The anti-atherogenic, anti-inflammatory, and vasomotor effects of statins on the arteries are well known, but there are no significant literature data about statins treatment effects on veins. This study describes the potential morphological changes that may occur in the venous wall in the case of the patients with chronic venous disease (CVD) which associates atorvastatin treatment for at least two years. The patients were clinically evaluated, and at the same time, a microscopic morphological analysis was performed on surgically removed veins fragments. The obtained results prove an improvement in the CVD prognosis, as well as a better postoperative evolution in these patients, and suggest an improvement in the blood flow in the vasa vasorum from the venous adventitia, as well as a potential phlebotonic and phlebotrophic effect of statins.
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