Thrombotic Events in Cancer Patients

Abstract

Cancer poses the highest clinical and social burden throughout the world and is the second cause of death after is chemic heart disease, although will be predicted the first in 2060. Cancer patients are high risk for thrombotic events that are characterized as the second cause of death after cancer itself. Thrombotic events seem to be increasing over recent years according to improved patients survival, novel thrombogenic cancer treatment and central catheter using. As we know thromboprophylaxis reduces the risk of VTE and primary prevention seems to be more effective way to reduce morbidity and mortality in these patients several criteria was designed to reduce this risk. Khorana risk score is the most important of them which designed for ambulatory cancer patients. Some other risk factors for thrombotic events consist of major abdominal surgery and prolonged immobility after surgery, use of thrombogenic medications (chemotherapy agents), old age, obesity, distant metastasis or advanced stage at the time of diagnosis, hyperthermic intraperitoneal chemotherapy (HIPEC) as a new surgery technique, anemia that requires blood transfusion that recommend special attention should be paid to them.