Author:
Elkaranshawy Hesham,Ezzat Hossam
Abstract
Mathematical models are formulated that describes the interaction between uninfected cells, infected cells, viruses, intracellular viral RNA, cytotoxic T-lymphocytes (CTLs), antibodies, and the hepatocyte proliferation of both uninfected and infected cells. The models used in this study incorporate certain biological connections that are believed to be crucial in understanding the interactions at play. By taking these relationships into account, we can draw logical conclusions with greater accuracy. This improves our ability to understand the origins of a disease, analyze clinical information, manage treatment plans, and identify new connections. These models can be applied to a variety of infectious diseases, such as human immunodeficiency virus (HIV), human papillomavirus (HPV), hepatitis B virus (HBV), hepatitis C virus (HCV), and Covid-19. An in-depth examination of the multiscale HCV model in relation to direct-acting antiviral agents is provided, but the findings can also be applied to other viruses.