Abstract
Neurological disorders represent a complex spectrum of conditions, ranging from neurodegenerative diseases to acute injuries, each posing unique challenges to treatment. This chapter delves into the emerging role of the NRF2 transcription factor as a molecular beacon with therapeutic implications in the realm of neurological disorders. NRF2, a master regulator of cellular defense mechanisms, orchestrates antioxidant responses and mitigates oxidative stress—processes intricately linked to neuroprotection. The chapter explores the intricate interplay between NRF2 and neurological pathologies, emphasizing its influence on the progression of conditions such as Alzheimer’s, Parkinson’s, and ischemic stroke. By dissecting the molecular pathways through which NRF2 modulates inflammation, oxidative damage, and apoptosis in the nervous system, we gain insights into potential therapeutic strategies. Exciting research on NRF2 activators, both natural and synthetic, offers promising avenues for drug development. Furthermore, the chapter navigates through preclinical and clinical studies, highlighting the potential of NRF2-targeted interventions in preserving neuronal function and promoting recovery. As we unravel the molecular intricacies of NRF2 in neurological contexts, this chapter serves as a guide to understanding its therapeutic potential, paving the way for innovative strategies aimed at mitigating the burden of neurological disorders.