Unlocking the Synergy: Exploring the Solubility Permeability Interplay in Microemulsion-Based Skin Drug Delivery

Abstract

In recent years, the pharmaceutical industry has witnessed a growing demand for drug delivery systems that are both effective and targeted. This surge in demand has sparked considerable interest in microemulsions as carriers for delivering drugs to the skin. This chapter aims to delve into the intricate relationship between solubility and permeability within microemulsion-based delivery systems, with the objective of unraveling the synergistic effects that govern their efficacy. This review investigates the physicochemical properties of microemulsions and their role in enhancing drug solubility and skin permeability. By examining current literature and experimental data, we aim to demonstrate how microemulsions can improve drug delivery, particularly in cases where conventional formulations struggle with poor solubility and limited skin permeation. The outcomes of this review chapter are poised to hold significant promise for the pharmaceutical industry by offering strategies for optimizing drug delivery systems. These findings improve our understanding of microemulsion-based drug delivery and guide the design of more effective formulations, advancing transdermal drug delivery. By highlighting key research findings and identifying areas for future investigation, this chapter aims to open new avenues for improving therapeutic outcomes and patient care in the field of dermatology and beyond.