Author:
Alejandro Valdez Julio,Mayorga Pedro,Villa Angulo Rafael,Villa Angulo Carlos
Abstract
Diabetes Mellitus Type 2 (DM2) is a complex and multifaceted disorder currently listed as one of the epidemics of the twenty-first century due to its prevalence and the adverse cardiovascular effects it causes. This chapter examines the relationships between base-pair positions in human mitochondrial genome and type 2 diabetes. The data included 510 complete mitochondrial genomes, of which 437 belonged to individuals with type 2 diabetes and 73 to healthy individuals. An alignment algorithm allowed inspecting and choosing a region with optional positions for analysis, a principal component analysis permitted viewing the data structure, and after a regression analysis, we declared three base-pair positions associated to DM2. Upon examination of the genome annotation, three genes were identified as potential candidates for association, one of which was previously linked to type 2 diabetes according to previous studies. This chapter offers further proof of a possible genetic link between type 2 diabetes and metabolic syndrome.
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