Formation of Polymeric Micelle-Mixed Micelles: The Drug Delivery, and Radiotherapy Applications, Interaction, and Investigation by Laser Light

Abstract

Surfactant micelles consist of a hydrophilic head that faces the solvent and a hydrophobic tail that faces the core. Mixed micelles, composed of several block copolymers, enhance medication administration. This text discusses the physical-chemical properties, in vivo and in vitro performance, and unique combinations of single and mixed copolymer micelles. It also investigates multifunctional mixed micelles that may respond to various stimuli for cancer treatment. Polymeric micelle-mixed micelles exhibit potential in the field of cancer radiation therapy. The purpose of encapsulating radiosensitizers in polymeric micelle-mixed micelles is to specifically target cancer cells and minimize harm to the rest of the body. Additionally, we can engineer polymeric micelle-mixed micelles to respond to specific conditions in the tumor microenvironment, like changes in pH or enzyme activity. Imaging compounds can be incorporated into mixed micelles to track the distribution and accumulation of tumor medicine during radiation therapy. To summarize, these adaptable nanocarriers can potentially enhance cancer treatment, specifically radiation therapy. However, further investigation is necessary to optimize the use of polymeric micelle-mixed micelles for irradiation. One technique that can determine the size distribution of particles, including multiple distributions and sizes of polymer micelles, whether single or mixed, is laser light scattering.