Author:
Elizbeth Alvarez-Sanchez Maria,Rojas Espinosa Oscar,César Torres-Romero Julio,Ameyatzin Robles Chávez Ereth,Estrella-Parra Edgar,Dolores Ponce Regalado María,Aragón Franco Raúl,Gadú Campos Saucedo Jose,López-Camarillo Cesar,Camacho Nuez Minerva,Fernández Sánchez Verónica
Abstract
Over the past two decades, several research groups have focused on the functioning of microRNAs (miRNAs), because many of them function as positive or negative endogenous regulators of processes that alter during the development of cancer. Prostate cancer is the second most commonly occurring cancer in men. New biomarkers are needed to support the diagnosis of prostate cancer. Although it is necessary to deepen the research on this molecule to explore its potential utility in the diagnosis, follow-up, and prognosis of cancer, our results support a role of miR-107 in the signaling cascades that allow cancer progression, and as shown here, in the progression of Prostate Cancer (PCa). These findings strongly suggest that miR-107 may be a potential circulating biomarker for the diagnosis and prognosis of prostate cancer.
Reference83 articles.
1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. Published online 2000. doi:10.1016/S0092-8674(00)81683-9
2. Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell. Published online 2011. doi:10.1016/j.cell.2011.02.013
3. The most common types of cancer [Internet]. 2021. Available from: https://gco.iarc.fr/today/home [Accessed: 2021-03-01]
4. World Cancer Report 2014 [Internet]. 2020. Available from: https://www.who.int/cancer/publications/WRC_2014/en/ [Accessed: 2020-07-01]
5. World Cancer Day: I Am and I Will [Internet]. 2021. Available from: https://www.paho.org/hq/index.php?option=com_content&view=article&id=15687:world-cancer-day-2020-i-am-and-i-will&Itemid=39809&lang=en [Accessed: 2021-03-01]