Abstract
This chapter delves into the multifaceted etiology of Buerger’s disease, also known as thromboangiitis obliterans (TAO), exploring a spectrum of factors contributing to its onset and the initiation of vascular inflammation. We comprehensively summarize our research findings regarding TAO’s pathogenesis, employing key indicators in our immune study, including cellular immunity, humoral immunization, and immunopathology. Our research unequivocally confirms TAO as an autoimmune disease characterized by multiple hypersensitivity reactions, primarily type III hypersensitivity, accompanied by type II, type IV, and type I reactions. Furthermore, our investigation uncovers a hypercoagulation state in the blood of TAO patients, shedding light on the intricate interplay between vascular immune dysregulation and thrombosis. These insights establish a robust foundation for implication diagnosis and treatment of this complex condition.
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