Author:
Irfan Shahzad,Muzaffar Humaira,Mukhtar Imran,Jabeen Farhat,Anwar Haseeb
Abstract
Recent studies have emphasized the multiple aspects of non-coding micro-RNAs in the regulation of pancreatic ß cells in type 2 diabetic patients. Thus, highlighting the significance of non-coding regions of the genome in regulating pancreatic endocrine cells. Functional dysregulation of pancreatic endocrine cells increases the incidence of metabolic disorders in otherwise healthy individuals. A precise understanding of the molecular biology of metabolic dysregulation is important from cellular and clinical perspectives. The current chapter will highlight the important recent findings from type 2 diabetic human patients and aims to enhance our current understanding of ß cell pathophysiology from a clinical perspective for the development of novel therapeutic approaches to control this global incidence.