Author:
Sivakumar Tharanikumar,Krithika Chandrasekaran,Tharanikumar Nandikha
Abstract
The aim of this study is to synthesize a new metallic aluminum and vanadium-free titanium alloy biomaterial for better osseointegration and implantation in the physiological system. The in vitro and in vivo methods were used to examine their biological compatibility, evaluated quantitatively and qualitatively. Results of Ga-Si-Ti alloy showed a higher ultimate tensile strength, yield strength and a higher percentage of elongation and more or less equal to Young\'s modulus when compared with the Ti and Ti-Ga alloy. In vivo study, a PA view of whole-body radiography all groups exhibited a substantial difference in the linear bone density of newly formed bone. Ga-Si-Ti group showed the highest bone mineral density than Ti and Ti-Ga group in the micro CT ex vivo study. The study exhibited a significant difference between the groups and the proportion of cortical bone volume to trabecular bone volume BV/TV in percentage. This is related to the anti-resorptive action of gallium and osteoblastic property of silicon, in addition to the benefits of commercial pure-Ti alloy.