Translational Research on Chagas Disease: Focusing on Drug Combination and Repositioning

Author:

André Vannier-Santos Marcos,Márcia Suarez-Fontes Ana,Almeida-Silva Juliana,Lifsitch Viçosa Alessandra,Aurora Chavez Perez Sandra,Marcel Hasslocher-Moreno Alejandro,Parreiras Estolano da Silveira Gabriel,Fernandes Portela Luciana,Magalhães Saraiva Roberto

Abstract

Chagas disease, caused by the protozoan Trypanosoma cruzi, is a major neglected disease endemic to Latin America, associated to significant morbimortality comprising a remarkable socioeconomic problem mainly for low-income tropical populations. The present chapter focuses translational research on Chagas disease, approaching drug combinations and repositioning, particularly exploiting the parasite oxidative stress by prospecting prooxidant compounds combined with antagonists of antioxidant systems, for developing low-cost and safe therapies for this infection. The pertinent literature on protozoal parasitic diseases is reviewed as well as on repurposing disulfiram aiming the combination with the Chagas disease drug of choice benznidazole. Both disulfiram and its first derivative sodium diethyldithiocarbamate (DETC) are able not only to inhibit p-glycoprotein, possibly reverting resistance phenotypes, but also to reduce toxicity of numerous other drugs, heavy metals, etc. Therefore, this innovation, presently in clinical research, may furnish a novel therapeutic for T. cruzi infections overcoming the adverse effects and refractory cases that impair the effectiveness of Chagas disease treatment.

Publisher

IntechOpen

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