Сlinical and Psychopathological Phenomenology of Mild Acute Drug-Induced Akathisia

Abstract

The study is devoted to the clinical and psychopathological phenomenology of mild acute drug-induced akathisia that occurs in the treatment of schizophrenia. The relationship between clinical symptoms and features of neurocognitive status with acute drug-induced akathisia resulting from the appointment of standardized antipsychotic therapy to patients was studied. It was found that patients with paranoid schizophrenia with mild acute drug-induced akathisia have more pronounced general psychopathological symptoms, such as anxiety, tension, depression, refusal to cooperate, weakening of impulsivity control, and congestion of mental experiences. According to the assessment of the risk profile of aggression, additional symptoms are more pronounced, such as anger, difficulties in delaying gratification (delayed reward), and affective lability. According to the results of the study of the neurocognitive status, markers of mild acute drug-induced akathisia were identified: impaired stability of active attention, impaired working memory, decreased automation of thinking, and impaired executive functions.