CAR-T Cells: A Breakthrough in Cancer Treatment

Abstract

Cancer is a significant health problem that demands ongoing innovation in treatment approaches. This chapter examines the evolution of cancer therapies, highlighting the limitations of conventional methods and the need for precise and effective solutions. Chimeric Antigen Receptor T cell therapy (CAR-T) emerges as a promising solution. The chapter delves into the fundamentals of CAR-T cell therapy, explaining the process of engineering these cells and their mechanism of action. It also discusses the clinical applications of CAR-T cell therapy in approved indications for hematologic malignancies. CAR-T cell therapy has expanded its scope to solid tumors and is exploring futuristic possibilities, such as combination therapies. Although there are challenges, ongoing research focuses on enhancing accessibility. The collaborative and interdisciplinary nature of cancer treatments is emphasized.