Author:
Abrahamyan Silva,Galoian Karina
Abstract
The proline-rich peptide (PRP-1) isolated from neurosecretory granules of the bovine neurohypophysis, produced by N.supraopticus and N.paraventricularis, has many potentially beneficial biological effects. PRP-1 has been shown to have the opposite effects on cell death in neurodegenerative and cancer diseases. It significantly reduces staurosporine-induced apoptosis of postnatal hippocampal cells, as well as doxorubicin-induced apoptosis of bone marrow monocytes and granulocytes, in both time- and dose-dependent manner. PRP-1 also exerts the opposite effect on the proliferation of bone marrow stromal cells obtained from normal humans and on the stromal cells isolated from human giant-cell tumor. PRP-1 cytostatically inhibits chondrosarcoma bulk tumor but exerts drastic cytotoxic effect on sarcomas cancer stem cells. The same peptide caused cell death through apoptosis in rats with Ehrlich Ascites Carcinoma model.
Reference57 articles.
1. Galoyan A. New polypeptides of hypothalamus: Isolation and primary structure. Proceeding NAS RA. 1996;96:555-570. DOI: 10.54503/0321-1339
2. Galoyan AA. Biochemistry of Novel Cardioactive Hormones and Immunomodulators of the Functional System Neurosecretory Hypothalamus–Endocrine Heart. Design, Nauka Publishers: Moscow; 1997. p. 240 ISBN: 5-02-022509-6
3. Galoyan A, Sarkissian J, Kipriyan T, Sarkissian E, Sulkhanyan R, Grigorian Y, et al. Comparison of the protection against neuronal injury by hypothalamic peptides and by dexamethasone. Neurochemical Research. 2000;25(12):1567-1578. DOI: 10.1023/A:1026662318816
4. Galoyan A, Sarkissian J, Kipriyan T, Sarkissian E, Chavushyan E, Sulkhanyan R, et al. Protective effects of proline-rich peptides against cobra venom and trauma induced neuronal injury. Neurochemical Research. 2001;26:1023-1038. DOI: 10.1023/A:1012353005489
5. Abrahamyan S, Meliksetyan I, Galoyan A. Immunohistochemical analysis of the brain immunomodulators (proline rich polypeptide and immunophilin) in the normal and pathological conditions. In: Proceedings in the International Conference “Biochemical and Mollecular-Biological Aspects of the Brain Immune System”; Yerevan. Tsakhkadzor. RA. September 15-19 2001. pp. 62-73