Abstract
Various polymorphisms in several genes appear to be involved in the development of chronic post-surgical pain (CPSP). These genes are involved in the transduction, transmission and modulation of a nociceptive impulse. Understanding the influence of such polymorphisms would lead to a better awareness of the underlying processing in CPSP, with the possibility of stratifying the risk of CPSP for individual patients. It may also identify new treatment options by targeting specific points in this pathway. We look into six genes—SCN9A, KCNS1, GCH1, COMT, OPRM1, OPRK1—that are involved in nociception, and look at current literature to support their involvement in the development of CPSP. We also describe the potential use of such information in clinical practice.