Affiliation:
1. University of Utah School of Medicine, Salt Lake City, Utah, USA
2. Department of Neurosurgery, University of Florida, Gainesville, Florida, USA
Abstract
Hyperbaric Oxygen Therapy (HBOT), the use of pure oxygen (100% O2) at high pressure (2–3 ATM), is gaining prominence as a tool for managing persistent post-concussive symptoms, otherwise known as post-concussion syndrome (PCS). Recent research has emerged that elucidates the mechanisms by which HBOT improves PCS. This article reviews the progression and pathophysiology of PCS, challenges in diagnosis, and novel imaging solutions. It also delves into recent advancements in the understanding of HBOT mechanisms and the benefits observed from HBOT in PCS patients. The discussion concludes with an examination of innovative imaging techniques, novel biomarkers, the potential role of data sharing, machine learning, and how these developments can advance the use of HBOT in the management of PCS.